gastroplus tm pbpk simulator program  (Simulations Plus Inc)

Journal: The AAPS Journal

Article Title: Clinical Pharmacokinetics of Buffered Propranolol Sublingual Tablet (Promptol™)—Application of a New “Physiologically Based” Model to Assess Absorption and Disposition

doi: 10.1208/s12248-013-9479-1

Figure Lengend Snippet: Summary of the Input Parameters Employed for the Gastroplus Simulation

Article Snippet: The computational program Gastroplus (version 6.0, Simulations Plus, Inc., Lancaster, CA, USA) was utilized for fitting of the data (see “ Methods ”) with slight modification.

Techniques: Molecular Weight, Solubility, Formulation, Drug discovery, Diffusion-based Assay, Clinical Proteomics, Concentration Assay, Extraction

Journal: The AAPS Journal

Article Title: Clinical Pharmacokinetics of Buffered Propranolol Sublingual Tablet (Promptol™)—Application of a New “Physiologically Based” Model to Assess Absorption and Disposition

doi: 10.1208/s12248-013-9479-1

Figure Lengend Snippet: The % absorption of propranolol in human tissue simulated using GastroPlus following sublingual administration of (a) 10 mg Promptol™, (b) 40 mg Inderal®, (c) 40 mg Promptol™, and (d) oral administration of 10 mg Inderal®. The open square boxes are the observed Cp-prop data (mean ± SD)

Article Snippet: The computational program Gastroplus (version 6.0, Simulations Plus, Inc., Lancaster, CA, USA) was utilized for fitting of the data (see “ Methods ”) with slight modification.

Techniques: